Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report
Joint Authors
Randall, R. Lor
Marcus, Karen J.
Marina, Neyssa
Granowetter, Linda
Grier, Holcombe E.
Womer, Richard B.
McIlvaine, Elizabeth
Krailo, Mark
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To associate baseline patient characteristics and relapse across consecutive COG studies.
Methods.
We analyzed risk factors for LESFT patients in three randomized COG trials.
We evaluated age at enrollment, primary site, gender, tumor size, and treatment (as randomized).
We estimated event-free survival (EFS, Kaplan-Meier) and compared risk across groups (log-rank test).
Characteristics were assessed by proportional hazards regression with the characteristic of interest as the only component.
Confidence intervals (CI) for RR were derived.
Factors related to outcome at level 0.05 were included in a multivariate regression model.
Results.
Between 12/1988 and 8/2005, 1444 patients were enrolled and data current to 2001, 2004, or 2008 were used.
Patients were with a median age of 12 years (0–45), 55% male and 88% Caucasian.
The 5-year EFS was 68.3% ± 1.3%.
In univariate analysis age, treatment, and tumor location were identified for inclusion in the multivariate model, and all remained significant (p < 0.01).
Since tumor size was not collected in the last study, the other two were reanalyzed.
This model identified age, treatment, tumor location, and tumor size as significant predictors.
Conclusion.
Age > 18 years, pelvic tumor, size > 8 cms, and chemotherapy without ifosfamide/etoposide significantly predict worse outcome.
AEWS0031 is NCT00006734, INT0091 and INT0054 designed before 1993 (unregistered).
American Psychological Association (APA)
Marina, Neyssa& Granowetter, Linda& Grier, Holcombe E.& Womer, Richard B.& Randall, R. Lor& Marcus, Karen J.…[et al.]. 2015. Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report. Complexity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076111
Modern Language Association (MLA)
Marina, Neyssa…[et al.]. Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report. Complexity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1076111
American Medical Association (AMA)
Marina, Neyssa& Granowetter, Linda& Grier, Holcombe E.& Womer, Richard B.& Randall, R. Lor& Marcus, Karen J.…[et al.]. Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report. Complexity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076111