Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes
المؤلفون المشاركون
Goldberg, Anna Carla
Piccinato, Carla A.
Antonioli, Eliane
Cohen, Moisés
Ferretti, Mario
Nader, Helena Bonciani
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Bone marrow mesenchymal stem cells (BM-MSCs) are considered a good source for cellular therapy in cartilage repair.
But, their potential to repair the extracellular matrix, in an osteoarthritic environment, is still controversial.
In osteoarthritis (OA), anti-inflammatory action and extracellular matrix production are important steps for cartilage healing.
This study examined the interaction of BM-MSC and OA-chondrocyte on the production of hyaluronan and inflammatory cytokines in a Transwell system.
We compared cocultured BM-MSCs and OA-chondrocytes with the individually cultured controls (monocultures).
There was a decrease in BM-MSCs cell count in coculture with OA-chondrocytes when compared to BM-MSCs alone.
In monoculture, BM-MSCs produced higher amounts of hyaluronan than OA-chondrocytes and coculture of BM-MSCs with OA-chondrocytes increased hyaluronan production per cell.
Hyaluronan synthase-1 mRNA expression was upregulated in BM-MSCs after coculture with OA-chondrocytes, whereas hyaluronidase-1 was downregulated.
After coculture, lower IL-6 levels were detected in BM-MSCs compared with OA-chondrocytes.
These results indicate that, in response to coculture with OA-chondrocytes, BM-MSCs change their behavior by increasing production of hyaluronan and decreasing inflammatory cytokines.
Our results indicate that BM-MSCs per se could be a potential tool for OA regenerative therapy, exerting short-term effects on the local microenvironment even when cell:cell contact is not occurring.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Antonioli, Eliane& Piccinato, Carla A.& Nader, Helena Bonciani& Cohen, Moisés& Goldberg, Anna Carla& Ferretti, Mario. 2015. Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Antonioli, Eliane…[et al.]. Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Antonioli, Eliane& Piccinato, Carla A.& Nader, Helena Bonciani& Cohen, Moisés& Goldberg, Anna Carla& Ferretti, Mario. Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر