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Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells
المؤلفون المشاركون
Pedreiro, S.
Laranjeira, Paula
Gomes, Joana
Pedrosa, Monia
Martinho, Antonio
Antunes, Brigida
Ribeiro, Tania
Santos, Francisco
Domingues, Rosario
Abecasis, Manuel
Trindade, Helder
Paiva, Artur
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-28
دولة النشر
مصر
عدد الصفحات
15
الملخص EN
The immunosuppressive properties of mesenchymal stromal/stem cells (MSC) rendered them an attractive therapeutic approach for immune disorders and an increasing body of evidence demonstrated their clinical value.
However, the influence of MSC on the function of specific immune cell populations, namely, monocyte subpopulations, is not well elucidated.
Here, we investigated the influence of human bone marrow MSC on the cytokine and chemokine expression by peripheral blood classical, intermediate and nonclassical monocytes, and myeloid dendritic cells (mDC), stimulated with lipopolysaccharide plus interferon (IFN)γ.
We found that MSC effectively inhibit tumor necrosis factor- (TNF-) α and macrophage inflammatory protein- (MIP-) 1β protein expression in monocytes and mDC, without suppressing CCR7 and CD83 protein expression.
Interestingly, mDC exhibited the highest degree of inhibition, for both TNF-α and MIP-1β, whereas the reduction of TNF-α expression was less marked for nonclassical monocytes.
Similarly, MSC decreased mRNA levels of interleukin- (IL-) 1β and IL-6 in classical monocytes, CCL3, CCL5, CXCL9, and CXCL10 in classical and nonclassical monocytes, and IL-1β and CXCL10 in mDC.
MSC do not impair the expression of maturation markers in monocytes and mDC under our experimental conditions; nevertheless, they hamper the proinflammatory function of monocytes and mDC, which may impede the development of inflammatory immune responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Laranjeira, Paula& Gomes, Joana& Pedreiro, S.& Pedrosa, Monia& Martinho, Antonio& Antunes, Brigida…[et al.]. 2015. Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells. Stem Cells International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076354
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Laranjeira, Paula…[et al.]. Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells. Stem Cells International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1076354
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Laranjeira, Paula& Gomes, Joana& Pedreiro, S.& Pedrosa, Monia& Martinho, Antonio& Antunes, Brigida…[et al.]. Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076354
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076354
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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