A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier
المؤلفون المشاركون
Sane, Hemangi
Paranjape, Amruta
Gandhi, Sushant
Sundaram, Jyothi
Shetty, Akshata
Biju, Hema
Bhagawanani, Khushboo
Kulkarni, Pooja
Gokulchandran, Nandini
Sharma, Alok
Badhe, Prerna
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-18
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Cerebral palsy is a nonprogressive heterogeneous group of neurological disorders with a growing rate of prevalence.
Recently, cellular therapy is emerging as a potential novel treatment strategy for cerebral palsy.
The various mechanisms by which cellular therapy works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis.
We conducted an open label, nonrandomized study on 40 cases of cerebral palsy with an aim of evaluating the benefit of cellular therapy in combination with rehabilitation.
These cases were administered autologous bone marrow mononuclear cells intrathecally.
The follow-up was carried out at 1 week, 3 months, and 6 months after the intervention.
Adverse events of the treatment were also monitored in this duration.
Overall, at six months, 95% of patients showed improvements.
The study population was further divided into diplegic, quadriplegic, and miscellaneous group of cerebral palsy.
On statistical analysis, a significant association was established between the symptomatic improvements and cell therapy in diplegic and quadriplegic cerebral palsy.
PET-CT scan done in 6 patients showed metabolic improvements in areas of the brain correlating to clinical improvements.
The results of this study demonstrate that cellular therapy may accelerate the development, reduce disability, and improve the quality of life of patients with cerebral palsy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharma, Alok& Sane, Hemangi& Gokulchandran, Nandini& Kulkarni, Pooja& Gandhi, Sushant& Sundaram, Jyothi…[et al.]. 2015. A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharma, Alok…[et al.]. A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharma, Alok& Sane, Hemangi& Gokulchandran, Nandini& Kulkarni, Pooja& Gandhi, Sushant& Sundaram, Jyothi…[et al.]. A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر