![](/images/graphics-bg.png)
A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier
Joint Authors
Sane, Hemangi
Paranjape, Amruta
Gandhi, Sushant
Sundaram, Jyothi
Shetty, Akshata
Biju, Hema
Bhagawanani, Khushboo
Kulkarni, Pooja
Gokulchandran, Nandini
Sharma, Alok
Badhe, Prerna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-18
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Cerebral palsy is a nonprogressive heterogeneous group of neurological disorders with a growing rate of prevalence.
Recently, cellular therapy is emerging as a potential novel treatment strategy for cerebral palsy.
The various mechanisms by which cellular therapy works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis.
We conducted an open label, nonrandomized study on 40 cases of cerebral palsy with an aim of evaluating the benefit of cellular therapy in combination with rehabilitation.
These cases were administered autologous bone marrow mononuclear cells intrathecally.
The follow-up was carried out at 1 week, 3 months, and 6 months after the intervention.
Adverse events of the treatment were also monitored in this duration.
Overall, at six months, 95% of patients showed improvements.
The study population was further divided into diplegic, quadriplegic, and miscellaneous group of cerebral palsy.
On statistical analysis, a significant association was established between the symptomatic improvements and cell therapy in diplegic and quadriplegic cerebral palsy.
PET-CT scan done in 6 patients showed metabolic improvements in areas of the brain correlating to clinical improvements.
The results of this study demonstrate that cellular therapy may accelerate the development, reduce disability, and improve the quality of life of patients with cerebral palsy.
American Psychological Association (APA)
Sharma, Alok& Sane, Hemangi& Gokulchandran, Nandini& Kulkarni, Pooja& Gandhi, Sushant& Sundaram, Jyothi…[et al.]. 2015. A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076384
Modern Language Association (MLA)
Sharma, Alok…[et al.]. A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076384
American Medical Association (AMA)
Sharma, Alok& Sane, Hemangi& Gokulchandran, Nandini& Kulkarni, Pooja& Gandhi, Sushant& Sundaram, Jyothi…[et al.]. A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076384