Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients
المؤلفون المشاركون
Mfinanga, Godfrey S.
Brokstad, Karl A.
Mustafa, Tehmina
Wiker, Harald G.
المصدر
Tuberculosis Research and Treatment
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
Tuberculous lymphadenitis is the most common form of extrapulmonary tuberculosis (TB) with a female and paediatric preponderance, postulated to be due to differences in the immune response.
The aim of this study was to analyze the differences in the serum cytokine levels of tuberculous lymphadenitis patients with respect to age and gender.
Methods.
A multiplex bead-based enzyme-linked immunosorbent assay was used to measure IFN-γ, TNF-α, GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-15, and IL-17 levels in sera of patients ( n = 86 ) and healthy controls ( n = 23 ) .
Results.
Levels of IFN-γ, TNF-α, GM-CSF, IL-1β, IL-2, IL-4, and IL-6 were higher in adult patients than in controls, while those of IL-12 were lower ( P < 0.05 ) .
Children had lower levels of TNF-α, GM-CSF, and IL-5 and higher levels of IL-2 compared with adult patients ( P < 0.05 ) .
The male adult patients had higher levels of IL-17 and lower levels of IL-12 compared with female adult patients ( P < 0.05 ) .
Conclusion.
There were significant differences in the levels of circulating cytokines with respect to gender and age.
Children had generally lower levels of cytokines as compared to adults, which could make them more susceptible.
Findings do not support that female preponderance is due to differences in immune response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mustafa, Tehmina& Brokstad, Karl A.& Mfinanga, Godfrey S.& Wiker, Harald G.. 2015. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mustafa, Tehmina…[et al.]. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1078434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mustafa, Tehmina& Brokstad, Karl A.& Mfinanga, Godfrey S.& Wiker, Harald G.. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1078434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر