Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients
Joint Authors
Mfinanga, Godfrey S.
Brokstad, Karl A.
Mustafa, Tehmina
Wiker, Harald G.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Tuberculous lymphadenitis is the most common form of extrapulmonary tuberculosis (TB) with a female and paediatric preponderance, postulated to be due to differences in the immune response.
The aim of this study was to analyze the differences in the serum cytokine levels of tuberculous lymphadenitis patients with respect to age and gender.
Methods.
A multiplex bead-based enzyme-linked immunosorbent assay was used to measure IFN-γ, TNF-α, GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-15, and IL-17 levels in sera of patients ( n = 86 ) and healthy controls ( n = 23 ) .
Results.
Levels of IFN-γ, TNF-α, GM-CSF, IL-1β, IL-2, IL-4, and IL-6 were higher in adult patients than in controls, while those of IL-12 were lower ( P < 0.05 ) .
Children had lower levels of TNF-α, GM-CSF, and IL-5 and higher levels of IL-2 compared with adult patients ( P < 0.05 ) .
The male adult patients had higher levels of IL-17 and lower levels of IL-12 compared with female adult patients ( P < 0.05 ) .
Conclusion.
There were significant differences in the levels of circulating cytokines with respect to gender and age.
Children had generally lower levels of cytokines as compared to adults, which could make them more susceptible.
Findings do not support that female preponderance is due to differences in immune response.
American Psychological Association (APA)
Mustafa, Tehmina& Brokstad, Karl A.& Mfinanga, Godfrey S.& Wiker, Harald G.. 2015. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078434
Modern Language Association (MLA)
Mustafa, Tehmina…[et al.]. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1078434
American Medical Association (AMA)
Mustafa, Tehmina& Brokstad, Karl A.& Mfinanga, Godfrey S.& Wiker, Harald G.. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078434