Bioactive compounds of flaxseed as natural antioxidants and anticancer
العناوين الأخرى
المواد الفعالة النشطة بيولوجيا في بذور الكتان كمضادات أكسدة طبيعية و مضادات للأورام السرطانية
المؤلفون المشاركون
Khalaf, Hasan Hasan Ali
al-Sadani, Rauf Muhammad Abd Allah
al-Umari, Huda Gharib
Abd al-Salam, Riham Sayyid
المصدر
Annals of Agricultural Science, Moshtohor
العدد
المجلد 57، العدد 2 (30 يونيو/حزيران 2019)، ص ص. 395-404، 10ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
The objective of this study was to investigate the content of biologically active compounds and antioxidant activity (AOA) of full fat flaxseed flour (FFF), roasted full fat flaxseed flour (RFFF), defatted flaxseed flour (DFF) and roasted defatted flaxseed flour (RDFF) flour as well as to evaluate anticancer effect of lignans ethanolic extracts from defatted and roasted defatted flaxseed for in vitro cytotoxicity against breast and colon carcinoma cell lines.
The results revealed that roasted defatted flaxseed flour samples (RDFF) contained higher values of crude protein (32.86% ), ash (6.60% ), crude fiber (14.03% ) and total carbohydrate (42.16% ) than other flaxseed flour samples.
Results showed that RDFF had significantly (P<0.05) the highest amounts of total phenolic contents, total flavonoid contents, tannins content and antioxidant activity (871.15 mg GAE/100g, 199.12 mg CE/100g, 83.51 mg CE/100g and 78.99% , respectively).
Meanwhile, FFF contained the lowest values (643.04 mg GAE/100g, 112.46 mg CE/100g, 60.33 mg CE/100g and 75.80% , respectively).
It was observed that, ferulic acid was the predominant phenolic acid in defatted flaxseed samples.
Also, Secoisolariciresinol diglucoside(SDG) is the predominant lignans precursor present in flaxseed.
Furthermore, DFF and RDFF were higher in lignans values compared to that of full fat and roasted full fat flaxseed flours.
Cytotoxicity effect of lignans ethanolic extracts from defatted and roasted defatted flaxseed on colon carcinoma cell line (HCT) and breast carcinoma cell line (MCF-7) increased as the extract concentration increased.
RDFF had strong anticancer activity toward two tested cell lines (MCF-7 and HCT) with the half maximal inhibitory concentration (IC50) values (29.0 and 31.4 µg/ml, respectively).
While, defatted flaxseed revealed anticancer activity against (HCT) cell line (with value 48.2 µg/ml of IC50) compared to (MCF-7) cell line at concentration under investigation (12.5, 25, 50 and 100 µg/ml of lignans extract).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalaf, Hasan Hasan Ali& al-Sadani, Rauf Muhammad Abd Allah& al-Umari, Huda Gharib& Abd al-Salam, Riham Sayyid. 2019. Bioactive compounds of flaxseed as natural antioxidants and anticancer. Annals of Agricultural Science, Moshtohor،Vol. 57, no. 2, pp.395-404.
https://search.emarefa.net/detail/BIM-1078804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalaf, Hasan Hasan Ali…[et al.]. Bioactive compounds of flaxseed as natural antioxidants and anticancer. Annals of Agricultural Science, Moshtohor Vol. 57, no. 2 (2019), pp.395-404.
https://search.emarefa.net/detail/BIM-1078804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalaf, Hasan Hasan Ali& al-Sadani, Rauf Muhammad Abd Allah& al-Umari, Huda Gharib& Abd al-Salam, Riham Sayyid. Bioactive compounds of flaxseed as natural antioxidants and anticancer. Annals of Agricultural Science, Moshtohor. 2019. Vol. 57, no. 2, pp.395-404.
https://search.emarefa.net/detail/BIM-1078804
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
-
رقم السجل
BIM-1078804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر