Association of RS 7903146 (CT)‎ single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus

المصدر

Suez Canal University Medical Journal

العدد

المجلد 23، العدد 2 (31 ديسمبر/كانون الأول 2020)، ص ص. 106-116، 11ص.

الناشر

جامعة قناة السويس كلية الطب

تاريخ النشر

2020-12-31

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Approximately 462 million people suffer from type 2 diabetes mellitus (T2DM) worldwide, and its prevalence is projected to increase to 7079 individuals per 100, 000 by 2030.

The rapid increase in the prevalence of this disease is likely a result of multiple environmental factors as increased food intake and decreased physical activity in genetically predisposed individuals.

Patients with T2DM are vulnerable to developing secondary complications like retinopathy, and nephropathy.

For that reason, great effort has been made to identify genes associated with T2DM.

Many loci were found to be associated with T2DM risk in various populations and ethnic groups as the transcription factor 7-like-2 gene (TCF7L2) gene (rs7903146) [C/T] polymorphism locus on chromosome 10q.

The TCF7L2 (rs7903146) (C/T) contributes to the disease through the Wnt/β-catenin signaling pathway affecting pancreatic islet development, expression of several genes involved in insulin granules exocytosis, and the incretin glucagon-like peptide 1 (GLP-1) gene.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nassar, Hasna M.. 2020. Association of RS 7903146 (CT) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus. Suez Canal University Medical Journal،Vol. 23, no. 2, pp.106-116.
https://search.emarefa.net/detail/BIM-1084673

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nassar, Hasna M.. Association of RS 7903146 (CT) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus. Suez Canal University Medical Journal Vol. 23, no. 2 (2020), pp.106-116.
https://search.emarefa.net/detail/BIM-1084673

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nassar, Hasna M.. Association of RS 7903146 (CT) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus. Suez Canal University Medical Journal. 2020. Vol. 23, no. 2, pp.106-116.
https://search.emarefa.net/detail/BIM-1084673

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 112-116

رقم السجل

BIM-1084673