Association of RS 7903146 (CT)‎ single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus

Source

Suez Canal University Medical Journal

Issue

Vol. 23, Issue 2 (31 Dec. 2020), pp.106-116, 11 p.

Publisher

Suez Canal University Faculty of Medicine

Publication Date

2020-12-31

Country of Publication

Egypt

No. of Pages

11

Main Topic

Diseases

Topics

Abstract EN

Approximately 462 million people suffer from type 2 diabetes mellitus (T2DM) worldwide, and its prevalence is projected to increase to 7079 individuals per 100, 000 by 2030.

The rapid increase in the prevalence of this disease is likely a result of multiple environmental factors as increased food intake and decreased physical activity in genetically predisposed individuals.

Patients with T2DM are vulnerable to developing secondary complications like retinopathy, and nephropathy.

For that reason, great effort has been made to identify genes associated with T2DM.

Many loci were found to be associated with T2DM risk in various populations and ethnic groups as the transcription factor 7-like-2 gene (TCF7L2) gene (rs7903146) [C/T] polymorphism locus on chromosome 10q.

The TCF7L2 (rs7903146) (C/T) contributes to the disease through the Wnt/β-catenin signaling pathway affecting pancreatic islet development, expression of several genes involved in insulin granules exocytosis, and the incretin glucagon-like peptide 1 (GLP-1) gene.

American Psychological Association (APA)

Nassar, Hasna M.. 2020. Association of RS 7903146 (CT) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus. Suez Canal University Medical Journal،Vol. 23, no. 2, pp.106-116.
https://search.emarefa.net/detail/BIM-1084673

Modern Language Association (MLA)

Nassar, Hasna M.. Association of RS 7903146 (CT) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus. Suez Canal University Medical Journal Vol. 23, no. 2 (2020), pp.106-116.
https://search.emarefa.net/detail/BIM-1084673

American Medical Association (AMA)

Nassar, Hasna M.. Association of RS 7903146 (CT) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus. Suez Canal University Medical Journal. 2020. Vol. 23, no. 2, pp.106-116.
https://search.emarefa.net/detail/BIM-1084673

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 112-116

Record ID

BIM-1084673