High performance liquid chromatographic method for the determination of piroxicam, naproxen, diclofenac sodium, and mefenamic acid in bulk drug and pharmaceutical preparations
المؤلفون المشاركون
Mahmud, Ruaa Muayyad
Dikran, Sarmad Bahjat
المصدر
Journal of Babylon University : Journal of Applied and Pure Sciences
العدد
المجلد 26، العدد 5 (31 مايو/أيار 2018)، ص ص. 387-399، 13ص.
الناشر
تاريخ النشر
2018-05-31
دولة النشر
العراق
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
A simple accurate and rapid reversed phase high performance liquid chromatographic method has been developed and validated for the determination of four nonsteroidal anti-inflammatory drugs; Piroxicam(PX), Naproxen(NAP), Diclofenac sodium(DCL) and Mefenamic acid(MFNC) in their pure form and different commercial pharmaceutical formulation.
The separation was performed on a NUCLEODUR® 100-5 C18ec (250 × 4.6 mm i.d.; particle size 5 μm) column as stationary phase with a mobile phase comprising of acetonitrile: deionized water acidified with 1% acetic acid in gradient mode.
The flow rate was 1.5 mL.min-1 at the temperature 35 oC and detection was carried out at 264 nm.
Separation has been completed within 8 min.
The retention times of Piroxicam, Naproxen, Diclofenac sodium, and Mefenamic acid were 4.267 min, 4.785 min, 6.555min, and 7.683min respectively.
The linearity for Piroxicam was in the range of 3–200 μg.mL-1 and for Naproxen and Mefenamic acid was in the range 1-200 μg.mL-1 , while for Diclofenac sodium was in the range 1.5–200 μg.mL-1 .
The proposed method was successfully applied for the determination of these drugs in their pure form and different pharmaceutical preparations (tablets, capsules, and ampoule) and there is no interference with additives.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dikran, Sarmad Bahjat& Mahmud, Ruaa Muayyad. 2018. High performance liquid chromatographic method for the determination of piroxicam, naproxen, diclofenac sodium, and mefenamic acid in bulk drug and pharmaceutical preparations. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 5, pp.387-399.
https://search.emarefa.net/detail/BIM-1093467
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dikran, Sarmad Bahjat& Mahmud, Ruaa Muayyad. High performance liquid chromatographic method for the determination of piroxicam, naproxen, diclofenac sodium, and mefenamic acid in bulk drug and pharmaceutical preparations. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 5 (2018), pp.387-399.
https://search.emarefa.net/detail/BIM-1093467
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dikran, Sarmad Bahjat& Mahmud, Ruaa Muayyad. High performance liquid chromatographic method for the determination of piroxicam, naproxen, diclofenac sodium, and mefenamic acid in bulk drug and pharmaceutical preparations. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 5, pp.387-399.
https://search.emarefa.net/detail/BIM-1093467
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 398-399
رقم السجل
BIM-1093467
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر