Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab
المؤلف
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance.
24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia.
The aim of the study was to examine how known predictors and adverse events interacted with adverse events using structural statistical methods.
Methods.
Five predictors (age, cyclophosphamide, total Ig and CD4/CD8 ratio prior RTX, and type of RTX maintenance regimen) and 4 adverse events (severe and chronic infections, hypogammaglobulinemia, and RTX discontinuation) were modeled in principal component and redundancy analyses.
Results.
The 5 predictors explained 51% of the variance of the GPA cohort.
Models including cyclophosphamide exposure and total Ig level predicted best adverse events.
However total Ig level has low R squared.
The 2 best combinations of adverse events explained 13% of the variance of the predictors and adverse events.
Only chronic infections were associated with combination of all adverse events ( P = 0.014 ).
Hypogammaglobulinemia did not seem associated with the other adverse events.
Conclusions.
Traditional risk factors for infections and hypogammaglobulinemia seemed to poorly predict adverse events in our GPA cohort.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Besada, Emilio. 2016. Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab. Autoimmune Diseases،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Besada, Emilio. Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab. Autoimmune Diseases No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1094987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Besada, Emilio. Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab. Autoimmune Diseases. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1094987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر