Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance.
24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia.
The aim of the study was to examine how known predictors and adverse events interacted with adverse events using structural statistical methods.
Methods.
Five predictors (age, cyclophosphamide, total Ig and CD4/CD8 ratio prior RTX, and type of RTX maintenance regimen) and 4 adverse events (severe and chronic infections, hypogammaglobulinemia, and RTX discontinuation) were modeled in principal component and redundancy analyses.
Results.
The 5 predictors explained 51% of the variance of the GPA cohort.
Models including cyclophosphamide exposure and total Ig level predicted best adverse events.
However total Ig level has low R squared.
The 2 best combinations of adverse events explained 13% of the variance of the predictors and adverse events.
Only chronic infections were associated with combination of all adverse events ( P = 0.014 ).
Hypogammaglobulinemia did not seem associated with the other adverse events.
Conclusions.
Traditional risk factors for infections and hypogammaglobulinemia seemed to poorly predict adverse events in our GPA cohort.
American Psychological Association (APA)
Besada, Emilio. 2016. Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab. Autoimmune Diseases،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094987
Modern Language Association (MLA)
Besada, Emilio. Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab. Autoimmune Diseases No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1094987
American Medical Association (AMA)
Besada, Emilio. Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab. Autoimmune Diseases. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1094987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094987