Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana
المؤلفون المشاركون
Adu, Patrick
Simpong, David Larbi
Takyi, Godfred
Ephraim, Richard K. D.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Blood transfusion is a therapeutic procedure usually undertaken in patients with severe anaemia.
In Ghana, severe anaemia is mostly due to malaria caused by severe Plasmodium falciparum infection, road traffic accidents, and haemoglobinopathy-induced acute haemolysis.
Method.
This cross-sectional study evaluated coinheritance of sickle cell haemoglobin variant and G6PD enzymopathy among individuals that donated blood at the Holy Trinity Hospital, Berekum, in the Brong-Ahafo Region, Ghana.
Demographic data and other pertinent information were captured using questionnaire.
Sickle cell haemoglobin variants were determined using cellulose acetate electrophoresis (pH 8.6).
Qualitative G6PD status and quantitative G6PD enzyme activity were determined using methaemoglobin reduction and Trinity Biotech G6PD test kit, respectively.
Results.
Prevalence of sickle cell trait (SCT) and G6PD enzymopathy coinheritance was 7%.
In addition, 19.5% of the donors had 10%–60% of normal G6PD enzyme activity suggesting that these donor units are prone to stressor-induced acute haemolysis when given to recipients.
Mild G6PD activity (p=0.03, OR: 2.410 (CI: 1.049–5.534)), commercial (p=0.020, OR: 5.609 (CI: 1.309–24.035)), and voluntary (p=0.034, OR: 2.404 (CI: 1.071–5.397)) donors were significantly associated with SCT.
Conclusion.
Screening for red cell pathologies must be incorporated into existing protocols for populations with high incidence of haemoglobinopathies to protect high-risk recipients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adu, Patrick& Simpong, David Larbi& Takyi, Godfred& Ephraim, Richard K. D.. 2016. Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana. Advances in Hematology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1095108
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adu, Patrick…[et al.]. Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana. Advances in Hematology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1095108
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adu, Patrick& Simpong, David Larbi& Takyi, Godfred& Ephraim, Richard K. D.. Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana. Advances in Hematology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1095108
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1095108
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر