Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana
Joint Authors
Adu, Patrick
Simpong, David Larbi
Takyi, Godfred
Ephraim, Richard K. D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Blood transfusion is a therapeutic procedure usually undertaken in patients with severe anaemia.
In Ghana, severe anaemia is mostly due to malaria caused by severe Plasmodium falciparum infection, road traffic accidents, and haemoglobinopathy-induced acute haemolysis.
Method.
This cross-sectional study evaluated coinheritance of sickle cell haemoglobin variant and G6PD enzymopathy among individuals that donated blood at the Holy Trinity Hospital, Berekum, in the Brong-Ahafo Region, Ghana.
Demographic data and other pertinent information were captured using questionnaire.
Sickle cell haemoglobin variants were determined using cellulose acetate electrophoresis (pH 8.6).
Qualitative G6PD status and quantitative G6PD enzyme activity were determined using methaemoglobin reduction and Trinity Biotech G6PD test kit, respectively.
Results.
Prevalence of sickle cell trait (SCT) and G6PD enzymopathy coinheritance was 7%.
In addition, 19.5% of the donors had 10%–60% of normal G6PD enzyme activity suggesting that these donor units are prone to stressor-induced acute haemolysis when given to recipients.
Mild G6PD activity (p=0.03, OR: 2.410 (CI: 1.049–5.534)), commercial (p=0.020, OR: 5.609 (CI: 1.309–24.035)), and voluntary (p=0.034, OR: 2.404 (CI: 1.071–5.397)) donors were significantly associated with SCT.
Conclusion.
Screening for red cell pathologies must be incorporated into existing protocols for populations with high incidence of haemoglobinopathies to protect high-risk recipients.
American Psychological Association (APA)
Adu, Patrick& Simpong, David Larbi& Takyi, Godfred& Ephraim, Richard K. D.. 2016. Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana. Advances in Hematology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1095108
Modern Language Association (MLA)
Adu, Patrick…[et al.]. Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana. Advances in Hematology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1095108
American Medical Association (AMA)
Adu, Patrick& Simpong, David Larbi& Takyi, Godfred& Ephraim, Richard K. D.. Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana. Advances in Hematology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1095108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095108