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Myeloablative Conditioning with PBSC Grafts for T Cell-Replete Haploidentical Donor Transplantation Using Posttransplant Cyclophosphamide
المؤلفون المشاركون
Morris, Lawrence
Solomon, Scott R.
Solh, Melhem
Holland, H. Kent
Bashey, Asad
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Relapse is the main cause of treatment failure after nonmyeloablative haploidentical transplant (haplo-HSCT).
In an attempt to reduce relapse, we have developed a myeloablative (MA) haplo-HSCT approach utilizing posttransplant cyclophosphamide (PT/Cy) and peripheral blood stem cells as the stem cell source.
We summarize the results of two consecutive clinical trials, using a busulfan-based ( n = 20 ) and a TBI-based MA preparative regimen ( n = 30 ), and analyze a larger cohort of 64 patients receiving MA haplo-HSCT.
All patients have engrafted with full donor chimerism and no late graft failures.
Grade III-IV acute GVHD and moderate-severe chronic GVHD occurred in 23% and 30%, respectively.
One-year NRM was 10%.
Predicted three-year overall survival, disease-free survival, and relapse were 53%, 53%, and 26%, respectively, in all patients and 79%, 74%, and 9%, respectively, in patients with a low/intermediate disease risk index (DRI).
In multivariate analysis, DRI was the most significant predictor of survival and relapse.
Use of TBI (versus busulfan) had no significant impact on survival but was associated with significantly less BK virus-associated hemorrhagic cystitis.
We contrast our results with other published reports of MA haplo-HSCT PT/Cy in the literature and attempt to define the comparative utility of MA haplo-HSCT to other methods of transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Solomon, Scott R.& Solh, Melhem& Morris, Lawrence& Holland, H. Kent& Bashey, Asad. 2016. Myeloablative Conditioning with PBSC Grafts for T Cell-Replete Haploidentical Donor Transplantation Using Posttransplant Cyclophosphamide. Advances in Hematology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1095112
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Solomon, Scott R.…[et al.]. Myeloablative Conditioning with PBSC Grafts for T Cell-Replete Haploidentical Donor Transplantation Using Posttransplant Cyclophosphamide. Advances in Hematology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1095112
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Solomon, Scott R.& Solh, Melhem& Morris, Lawrence& Holland, H. Kent& Bashey, Asad. Myeloablative Conditioning with PBSC Grafts for T Cell-Replete Haploidentical Donor Transplantation Using Posttransplant Cyclophosphamide. Advances in Hematology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1095112
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1095112
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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