CYP4F2 (rs2108622)‎ Gene Polymorphism Association with Age-Related Macular Degeneration

الملخص EN

Background.

Age-related macular degeneration is the leading cause of blindness in elderly individuals where aetiology and pathophysiology of age-related macular degeneration are not absolutely clear.

Purpose.

To determine the frequency of the genotype of rs2108622 in patients with early and exudative age-related macular degeneration.

Methods.

The study enrolled 190 patients with early age-related macular degeneration, 181 patients with exudative age-related macular degeneration (eAMD), and a random sample of 210 subjects from the general population (control group).

The genotyping of rs2108622 was carried out using the real-time polymerase chain reaction method.

Results.

The analysis of rs2108622 gene polymorphism did not reveal any differences in the distribution of C/C, C/T, and T/T genotypes between the early AMD group, the eAMD group, and the control group.

The CYP4F2 (1347C>T) T/T genotype was more frequent in males with eAMD compared to females (10.2% versus 0.8%; p = 0.0052 ); also T/T genotype was less frequently present in eAMD females compared to healthy control females (0.8% versus 6.2%; p = 0.027 ).

Conclusion.

Rs2108622 gene polymorphism had no predominant effect on the development of early AMD and eAMD.

The T/T genotype was more frequent in males with eAMD compared to females and less frequently present in eAMD females compared to healthy females.