CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration
Joint Authors
Sakiene, Ruta
Vilkeviciute, Alvita
Kriauciuniene, Loresa
Balciuniene, Vilma Jurate
Buteikiene, Dovile
Miniauskiene, Goda
Liutkeviciene, Rasa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Age-related macular degeneration is the leading cause of blindness in elderly individuals where aetiology and pathophysiology of age-related macular degeneration are not absolutely clear.
Purpose.
To determine the frequency of the genotype of rs2108622 in patients with early and exudative age-related macular degeneration.
Methods.
The study enrolled 190 patients with early age-related macular degeneration, 181 patients with exudative age-related macular degeneration (eAMD), and a random sample of 210 subjects from the general population (control group).
The genotyping of rs2108622 was carried out using the real-time polymerase chain reaction method.
Results.
The analysis of rs2108622 gene polymorphism did not reveal any differences in the distribution of C/C, C/T, and T/T genotypes between the early AMD group, the eAMD group, and the control group.
The CYP4F2 (1347C>T) T/T genotype was more frequent in males with eAMD compared to females (10.2% versus 0.8%; p = 0.0052 ); also T/T genotype was less frequently present in eAMD females compared to healthy control females (0.8% versus 6.2%; p = 0.027 ).
Conclusion.
Rs2108622 gene polymorphism had no predominant effect on the development of early AMD and eAMD.
The T/T genotype was more frequent in males with eAMD compared to females and less frequently present in eAMD females compared to healthy females.
American Psychological Association (APA)
Sakiene, Ruta& Vilkeviciute, Alvita& Kriauciuniene, Loresa& Balciuniene, Vilma Jurate& Buteikiene, Dovile& Miniauskiene, Goda…[et al.]. 2016. CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration. Advances in Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1095320
Modern Language Association (MLA)
Sakiene, Ruta…[et al.]. CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration. Advances in Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1095320
American Medical Association (AMA)
Sakiene, Ruta& Vilkeviciute, Alvita& Kriauciuniene, Loresa& Balciuniene, Vilma Jurate& Buteikiene, Dovile& Miniauskiene, Goda…[et al.]. CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1095320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095320