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Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril
المؤلفون المشاركون
Abareshi, Azam
Anaeigoudari, Akbar
Norouzi, Fatemeh
Shafei, Mohammad Naser
Khazaei, Majid
Hosseini, Mahmoud
Boskabady, Mohammad Hossein
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Renin-angiotensin system has a role in inflammation and also is involved in many brain functions such as learning, memory, and emotion.
Neuroimmune factors have been proposed as the contributors to the pathogenesis of memory impairments.
In the present study, the effect of captopril on spatial memory and synaptic plasticity impairments induced by lipopolysaccharide (LPS) was investigated.
Methods.
The rats were divided and treated into control (saline), LPS (1 mg/kg), LPS-captopril (LPS-Capto; 50 mg/kg captopril before LPS), and captopril groups (50 mg/kg) before saline.
Morris water maze was done.
Long-term potentiation (LTP) from CA1 area of hippocampus was assessed by 100 Hz stimulation in the ipsilateral Schaffer collateral pathway.
Results.
In the LPS group, the spent time and traveled path to reach the platform were longer than those in the control, while, in the LPS-Capto group, they were shorter than those in the LPS group.
Moreover, the slope and amplitude of field excitatory postsynaptic potential (fEPSP) decreased in the LPS group, as compared to the control group, whereas, in the LPS-Capto group, they increased compared to the LPS group.
Conclusion.
The results of the present study showed that captopril improved the LPS-induced memory and LTP impairments induced by LPS in rats.
Further investigations are required in order to better understand the exact responsible mechanism(s).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abareshi, Azam& Anaeigoudari, Akbar& Norouzi, Fatemeh& Shafei, Mohammad Naser& Boskabady, Mohammad Hossein& Khazaei, Majid…[et al.]. 2016. Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril. Advances in Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1095335
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abareshi, Azam…[et al.]. Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril. Advances in Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1095335
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abareshi, Azam& Anaeigoudari, Akbar& Norouzi, Fatemeh& Shafei, Mohammad Naser& Boskabady, Mohammad Hossein& Khazaei, Majid…[et al.]. Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1095335
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1095335
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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