Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril
Joint Authors
Abareshi, Azam
Anaeigoudari, Akbar
Norouzi, Fatemeh
Shafei, Mohammad Naser
Khazaei, Majid
Hosseini, Mahmoud
Boskabady, Mohammad Hossein
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Renin-angiotensin system has a role in inflammation and also is involved in many brain functions such as learning, memory, and emotion.
Neuroimmune factors have been proposed as the contributors to the pathogenesis of memory impairments.
In the present study, the effect of captopril on spatial memory and synaptic plasticity impairments induced by lipopolysaccharide (LPS) was investigated.
Methods.
The rats were divided and treated into control (saline), LPS (1 mg/kg), LPS-captopril (LPS-Capto; 50 mg/kg captopril before LPS), and captopril groups (50 mg/kg) before saline.
Morris water maze was done.
Long-term potentiation (LTP) from CA1 area of hippocampus was assessed by 100 Hz stimulation in the ipsilateral Schaffer collateral pathway.
Results.
In the LPS group, the spent time and traveled path to reach the platform were longer than those in the control, while, in the LPS-Capto group, they were shorter than those in the LPS group.
Moreover, the slope and amplitude of field excitatory postsynaptic potential (fEPSP) decreased in the LPS group, as compared to the control group, whereas, in the LPS-Capto group, they increased compared to the LPS group.
Conclusion.
The results of the present study showed that captopril improved the LPS-induced memory and LTP impairments induced by LPS in rats.
Further investigations are required in order to better understand the exact responsible mechanism(s).
American Psychological Association (APA)
Abareshi, Azam& Anaeigoudari, Akbar& Norouzi, Fatemeh& Shafei, Mohammad Naser& Boskabady, Mohammad Hossein& Khazaei, Majid…[et al.]. 2016. Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril. Advances in Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1095335
Modern Language Association (MLA)
Abareshi, Azam…[et al.]. Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril. Advances in Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1095335
American Medical Association (AMA)
Abareshi, Azam& Anaeigoudari, Akbar& Norouzi, Fatemeh& Shafei, Mohammad Naser& Boskabady, Mohammad Hossein& Khazaei, Majid…[et al.]. Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril. Advances in Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1095335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1095335