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Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik
المؤلفون المشاركون
Turgeon O’Brien, Huguette
Blanchet, Rosanne
Gagné, Doris
Lauzière, Julie
Vézina, Carole
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs.
Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively.
IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%.
Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level ( P < 0.0001 ).
The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%).
The prevalence of anemia was 15%.
The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%, P = 0.083 ).
Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE.
Our results confirm that Inuit children are at particularly high risk for iron deficiency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Turgeon O’Brien, Huguette& Blanchet, Rosanne& Gagné, Doris& Lauzière, Julie& Vézina, Carole. 2016. Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. Anemia،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096517
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Turgeon O’Brien, Huguette…[et al.]. Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. Anemia No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096517
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Turgeon O’Brien, Huguette& Blanchet, Rosanne& Gagné, Doris& Lauzière, Julie& Vézina, Carole. Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. Anemia. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096517
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096517
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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