Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik
Joint Authors
Turgeon O’Brien, Huguette
Blanchet, Rosanne
Gagné, Doris
Lauzière, Julie
Vézina, Carole
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs.
Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively.
IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%.
Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level ( P < 0.0001 ).
The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%).
The prevalence of anemia was 15%.
The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%, P = 0.083 ).
Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE.
Our results confirm that Inuit children are at particularly high risk for iron deficiency.
American Psychological Association (APA)
Turgeon O’Brien, Huguette& Blanchet, Rosanne& Gagné, Doris& Lauzière, Julie& Vézina, Carole. 2016. Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. Anemia،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096517
Modern Language Association (MLA)
Turgeon O’Brien, Huguette…[et al.]. Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. Anemia No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096517
American Medical Association (AMA)
Turgeon O’Brien, Huguette& Blanchet, Rosanne& Gagné, Doris& Lauzière, Julie& Vézina, Carole. Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. Anemia. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096517