Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats
المؤلفون المشاركون
du Plessis, Jan B.
Bekker, Zanelle
Walubo, Andrew
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity.
Male Sprague-Dawley (SD) rats were divided into four groups (saline (S), NVP, INH, and PAR) of 25 animals each.
The drugs were administered daily for 42 days at therapeutic doses (NVP 200 mg/kg, PAR 500 mg/kg, and INH 20 mg/kg) to the respective groups by oral gavage and five rats per group were sacrificed weekly.
All the three drugs induced a subclinical liver injury in the first 2-3 weeks followed by healing, indicating adaption.
The liver injury was pathologically similar and was associated with immune stimulation and increased cytochrome P450 activity.
NVP- and PAR-induced liver injury lasted up to 14 days while that for INH lasted for 28 days.
NVP-induced liver injury was associated with increased IL-2, CD4 count, and CYP3A2 activity, followed by increased IL-10 during the healing phase.
In conclusion, the initial drug-induced subclinical liver injury, its spontaneous healing, and the associated adaptive immune response have been demonstrated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bekker, Zanelle& Walubo, Andrew& du Plessis, Jan B.. 2016. Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096619
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bekker, Zanelle…[et al.]. Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1096619
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bekker, Zanelle& Walubo, Andrew& du Plessis, Jan B.. Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096619
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096619
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر