Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats
Joint Authors
du Plessis, Jan B.
Bekker, Zanelle
Walubo, Andrew
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity.
Male Sprague-Dawley (SD) rats were divided into four groups (saline (S), NVP, INH, and PAR) of 25 animals each.
The drugs were administered daily for 42 days at therapeutic doses (NVP 200 mg/kg, PAR 500 mg/kg, and INH 20 mg/kg) to the respective groups by oral gavage and five rats per group were sacrificed weekly.
All the three drugs induced a subclinical liver injury in the first 2-3 weeks followed by healing, indicating adaption.
The liver injury was pathologically similar and was associated with immune stimulation and increased cytochrome P450 activity.
NVP- and PAR-induced liver injury lasted up to 14 days while that for INH lasted for 28 days.
NVP-induced liver injury was associated with increased IL-2, CD4 count, and CYP3A2 activity, followed by increased IL-10 during the healing phase.
In conclusion, the initial drug-induced subclinical liver injury, its spontaneous healing, and the associated adaptive immune response have been demonstrated.
American Psychological Association (APA)
Bekker, Zanelle& Walubo, Andrew& du Plessis, Jan B.. 2016. Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096619
Modern Language Association (MLA)
Bekker, Zanelle…[et al.]. Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1096619
American Medical Association (AMA)
Bekker, Zanelle& Walubo, Andrew& du Plessis, Jan B.. Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096619