The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism
المؤلفون المشاركون
Moniruzzaman, Md.
Sharmin Ani, Nushrat
Chakraborty, Sudip
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Murraya koenigii L.
is a perennial shrub, belonging to the family Rutaceae.
Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation.
Although researchers have revealed the antinociceptive effects of this plant’s leaves during past few years, the mechanisms underlying these effects are still unknown.
Therefore, the present study evaluated some antinociceptive mechanisms of the methanolic extract of M.
koenigii (MEMK) leaves along with its antinociceptive potential using several animal models.
The antinociceptive effects of MEMK were evaluated using formalin-induced licking and acetic acid-induced writhing tests at the doses of 50, 100, and 200 mg/kg.
In addition, we also justified the possible participations of glutamatergic system and ATP-sensitive potassium channels in the observed activities.
Our results demonstrated that MEMK significantly (p<0.01) inhibited the pain thresholds induced by formalin and acetic acid in a dose-dependent manner.
MEMK also significantly (p<0.01) suppressed glutamate-induced pain.
Moreover, pretreatment with glibenclamide (an ATP-sensitive potassium channel blocker) at 10 mg/kg significantly (p<0.05) reversed the MEMK-mediated antinociception.
These revealed that MEMK might have the potential to interact with glutamatergic system and the ATP-sensitive potassium channels to exhibit its antinociceptive activities.
Therefore, our results strongly support the antinociceptive effects of M.
koenigii leaves and provide scientific basis of their analgesic uses in the traditional medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharmin Ani, Nushrat& Chakraborty, Sudip& Moniruzzaman, Md.. 2016. The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096622
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharmin Ani, Nushrat…[et al.]. The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1096622
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharmin Ani, Nushrat& Chakraborty, Sudip& Moniruzzaman, Md.. The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096622
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096622
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر