The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism
Joint Authors
Moniruzzaman, Md.
Sharmin Ani, Nushrat
Chakraborty, Sudip
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Murraya koenigii L.
is a perennial shrub, belonging to the family Rutaceae.
Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation.
Although researchers have revealed the antinociceptive effects of this plant’s leaves during past few years, the mechanisms underlying these effects are still unknown.
Therefore, the present study evaluated some antinociceptive mechanisms of the methanolic extract of M.
koenigii (MEMK) leaves along with its antinociceptive potential using several animal models.
The antinociceptive effects of MEMK were evaluated using formalin-induced licking and acetic acid-induced writhing tests at the doses of 50, 100, and 200 mg/kg.
In addition, we also justified the possible participations of glutamatergic system and ATP-sensitive potassium channels in the observed activities.
Our results demonstrated that MEMK significantly (p<0.01) inhibited the pain thresholds induced by formalin and acetic acid in a dose-dependent manner.
MEMK also significantly (p<0.01) suppressed glutamate-induced pain.
Moreover, pretreatment with glibenclamide (an ATP-sensitive potassium channel blocker) at 10 mg/kg significantly (p<0.05) reversed the MEMK-mediated antinociception.
These revealed that MEMK might have the potential to interact with glutamatergic system and the ATP-sensitive potassium channels to exhibit its antinociceptive activities.
Therefore, our results strongly support the antinociceptive effects of M.
koenigii leaves and provide scientific basis of their analgesic uses in the traditional medicine.
American Psychological Association (APA)
Sharmin Ani, Nushrat& Chakraborty, Sudip& Moniruzzaman, Md.. 2016. The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096622
Modern Language Association (MLA)
Sharmin Ani, Nushrat…[et al.]. The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1096622
American Medical Association (AMA)
Sharmin Ani, Nushrat& Chakraborty, Sudip& Moniruzzaman, Md.. The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096622