Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study
المؤلفون المشاركون
Saleem, Mohamed T. S.
Reddy, Rajitha Bodd
Punuru, Priyanka
Chakka, Gopinath
Karunakaran, Gauthaman
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The present study was designed to investigate the role of combined administration of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion injury in rat.
Male Wistar albino rats were divided into five groups (n=6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow).
Combination of Ramipril and Candesartan when compared to the monotherapy significantly increased the levels of superoxide dismutase, reduced glutathione, catalase, and nitric oxide and decreased the levels of thiobarbituric acid reactive substances.
In addition, the superior protective role of combination of Ramipril and Candesartan on ischemia induced myocardial damage was further confirmed by well preserved myocardial tissue architecture in light microscopy and transmission electron microscopy analysis studies.
The combination was proved to be effective in salvaging the myocardial tissue against ischemic reperfusion injury when compared to the monotherapy of individual drugs and further investigations on protective mechanism of drugs by increasing the nitric oxide level at molecular levels are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saleem, Mohamed T. S.& Reddy, Rajitha Bodd& Punuru, Priyanka& Chakka, Gopinath& Karunakaran, Gauthaman. 2016. Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096625
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saleem, Mohamed T. S.…[et al.]. Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096625
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saleem, Mohamed T. S.& Reddy, Rajitha Bodd& Punuru, Priyanka& Chakka, Gopinath& Karunakaran, Gauthaman. Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096625
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096625
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر