Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study
Joint Authors
Saleem, Mohamed T. S.
Reddy, Rajitha Bodd
Punuru, Priyanka
Chakka, Gopinath
Karunakaran, Gauthaman
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study was designed to investigate the role of combined administration of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion injury in rat.
Male Wistar albino rats were divided into five groups (n=6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow).
Combination of Ramipril and Candesartan when compared to the monotherapy significantly increased the levels of superoxide dismutase, reduced glutathione, catalase, and nitric oxide and decreased the levels of thiobarbituric acid reactive substances.
In addition, the superior protective role of combination of Ramipril and Candesartan on ischemia induced myocardial damage was further confirmed by well preserved myocardial tissue architecture in light microscopy and transmission electron microscopy analysis studies.
The combination was proved to be effective in salvaging the myocardial tissue against ischemic reperfusion injury when compared to the monotherapy of individual drugs and further investigations on protective mechanism of drugs by increasing the nitric oxide level at molecular levels are needed.
American Psychological Association (APA)
Saleem, Mohamed T. S.& Reddy, Rajitha Bodd& Punuru, Priyanka& Chakka, Gopinath& Karunakaran, Gauthaman. 2016. Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096625
Modern Language Association (MLA)
Saleem, Mohamed T. S.…[et al.]. Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096625
American Medical Association (AMA)
Saleem, Mohamed T. S.& Reddy, Rajitha Bodd& Punuru, Priyanka& Chakka, Gopinath& Karunakaran, Gauthaman. Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096625