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Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction
المؤلفون المشاركون
Qi, Yu
Uchida, Tokujiro
Yamamoto, Mamoru
Yamamoto, Yudai
Kido, Koji
Ito, Hiroyuki
Ohno, Nagara
Asahara, Miho
Yamada, Yoshitsugu
Yamaguchi, Osamu
Mitaka, Chieko
Tomita, Makoto
Makita, Koshi
المصدر
Anesthesiology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
This study aimed to determine the perioperative change in serum double-strand DNA (dsDNA) as a marker potentially reflecting neutrophil extracellular trap concentration in samples from patients undergoing cardiac surgery and to analyze a relationship between serum dsDNA concentrations and perioperative renal dysfunction.
Methods.
Serum dsDNA concentrations in samples that were collected during a previously conducted, prospective, multicenter, observational study were measured.
Eighty patients undergoing elective cardiac surgery were studied.
Serum samples were collected at baseline, immediately after surgery, and the day after surgery (POD-1).
Results.
Serum dsDNA concentration was significantly increased from baseline (median, 398 ng/mL [interquartile range, 372–475 ng/mL]) to immediately after surgery (median, 540 ng/mL [437–682 ng/mL], p < 0.001 ), and they were reduced by POD-1 (median, 323 ng/mL [256–436 ng/mL]).
The difference in serum creatinine concentration between baseline and POD-1 was correlated with dsDNA concentration on POD-1 ( r s = 0.61 , p < 0.001 ).
Conclusions.
In patients undergoing cardiac surgery, serum dsDNA concentration is elevated postoperatively.
Prolonged elevation in dsDNA concentration is correlated with perioperative renal dysfunction.
Further large-scale studies are needed to determine the relationship between serum concentration of circulating dsDNA and perioperative renal dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qi, Yu& Uchida, Tokujiro& Yamamoto, Mamoru& Yamamoto, Yudai& Kido, Koji& Ito, Hiroyuki…[et al.]. 2016. Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction. Anesthesiology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096661
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qi, Yu…[et al.]. Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction. Anesthesiology Research and Practice No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096661
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qi, Yu& Uchida, Tokujiro& Yamamoto, Mamoru& Yamamoto, Yudai& Kido, Koji& Ito, Hiroyuki…[et al.]. Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction. Anesthesiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096661
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096661
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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