![](/images/graphics-bg.png)
Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction
Joint Authors
Qi, Yu
Uchida, Tokujiro
Yamamoto, Mamoru
Yamamoto, Yudai
Kido, Koji
Ito, Hiroyuki
Ohno, Nagara
Asahara, Miho
Yamada, Yoshitsugu
Yamaguchi, Osamu
Mitaka, Chieko
Tomita, Makoto
Makita, Koshi
Source
Anesthesiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
This study aimed to determine the perioperative change in serum double-strand DNA (dsDNA) as a marker potentially reflecting neutrophil extracellular trap concentration in samples from patients undergoing cardiac surgery and to analyze a relationship between serum dsDNA concentrations and perioperative renal dysfunction.
Methods.
Serum dsDNA concentrations in samples that were collected during a previously conducted, prospective, multicenter, observational study were measured.
Eighty patients undergoing elective cardiac surgery were studied.
Serum samples were collected at baseline, immediately after surgery, and the day after surgery (POD-1).
Results.
Serum dsDNA concentration was significantly increased from baseline (median, 398 ng/mL [interquartile range, 372–475 ng/mL]) to immediately after surgery (median, 540 ng/mL [437–682 ng/mL], p < 0.001 ), and they were reduced by POD-1 (median, 323 ng/mL [256–436 ng/mL]).
The difference in serum creatinine concentration between baseline and POD-1 was correlated with dsDNA concentration on POD-1 ( r s = 0.61 , p < 0.001 ).
Conclusions.
In patients undergoing cardiac surgery, serum dsDNA concentration is elevated postoperatively.
Prolonged elevation in dsDNA concentration is correlated with perioperative renal dysfunction.
Further large-scale studies are needed to determine the relationship between serum concentration of circulating dsDNA and perioperative renal dysfunction.
American Psychological Association (APA)
Qi, Yu& Uchida, Tokujiro& Yamamoto, Mamoru& Yamamoto, Yudai& Kido, Koji& Ito, Hiroyuki…[et al.]. 2016. Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction. Anesthesiology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096661
Modern Language Association (MLA)
Qi, Yu…[et al.]. Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction. Anesthesiology Research and Practice No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096661
American Medical Association (AMA)
Qi, Yu& Uchida, Tokujiro& Yamamoto, Mamoru& Yamamoto, Yudai& Kido, Koji& Ito, Hiroyuki…[et al.]. Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction. Anesthesiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096661