Synthesis and Assessment of Antibacterial Activities of Ruthenium(III)‎ Mixed Ligand Complexes Containing 1,10-Phenanthroline and Guanide

الملخص EN

In this work, two complexes of ruthenium(III) ([Ru(phen)2Cl2]Cl·2H2O and [Ru(phen)2(G)Cl]2Cl·H2O) were synthesized from 1,10-phenanthroline alone as well as from both 1,10-phenanthroline and guanide.

The synthesis was checked using halide test, conductance measurement, and spectroscopic (ICP-OES, FTIR, and UV/Vis) analysis.

Their in vitro antibacterial activities were also investigated on two Gram-positive (Staphylococcus aureus (S.

aureus) and methicillin resistant Staphylococcus aureus (MRSA)) and two Gram-negative (Escherichia coli (E.

coli) and Klebsiella pneumoniae (K.

pneumoniae)) bacteria.

These complexes showed wide-range better activities than the commercially available controls (Chloramphenicol and Ciprofloxacin) against even the most drug resistant K.

pneumoniae.

[Ru(phen)2(G)Cl]2Cl·H2O inhibited S.

aureus, MRSA, E.

coli, and K.

pneumoniae by 17.5%, 27.4%, 16%, and 52%, respectively, better than Chloramphenicol.

It also inhibited these pathogens by 5.9%, 5.1%, 2.3%, and 17.2%, respectively, better than Ciprofloxacin.

Similarly, [Ru(Phen)2(Cl)2]Cl·2H2O inhibited these pathogens by 11%, 8.7%, 0.1%, and 31.2%, respectively, better than Chloramphenicol.

Therefore, after in vivo cytotoxicity investigations, these compounds can be considered as potential antibiotic drugs.