Synthesis and Assessment of Antibacterial Activities of Ruthenium(III) Mixed Ligand Complexes Containing 1,10-Phenanthroline and Guanide
Joint Authors
Abebe, Atakilt
Hailemariam, Tizazu
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this work, two complexes of ruthenium(III) ([Ru(phen)2Cl2]Cl·2H2O and [Ru(phen)2(G)Cl]2Cl·H2O) were synthesized from 1,10-phenanthroline alone as well as from both 1,10-phenanthroline and guanide.
The synthesis was checked using halide test, conductance measurement, and spectroscopic (ICP-OES, FTIR, and UV/Vis) analysis.
Their in vitro antibacterial activities were also investigated on two Gram-positive (Staphylococcus aureus (S.
aureus) and methicillin resistant Staphylococcus aureus (MRSA)) and two Gram-negative (Escherichia coli (E.
coli) and Klebsiella pneumoniae (K.
pneumoniae)) bacteria.
These complexes showed wide-range better activities than the commercially available controls (Chloramphenicol and Ciprofloxacin) against even the most drug resistant K.
pneumoniae.
[Ru(phen)2(G)Cl]2Cl·H2O inhibited S.
aureus, MRSA, E.
coli, and K.
pneumoniae by 17.5%, 27.4%, 16%, and 52%, respectively, better than Chloramphenicol.
It also inhibited these pathogens by 5.9%, 5.1%, 2.3%, and 17.2%, respectively, better than Ciprofloxacin.
Similarly, [Ru(Phen)2(Cl)2]Cl·2H2O inhibited these pathogens by 11%, 8.7%, 0.1%, and 31.2%, respectively, better than Chloramphenicol.
Therefore, after in vivo cytotoxicity investigations, these compounds can be considered as potential antibiotic drugs.
American Psychological Association (APA)
Abebe, Atakilt& Hailemariam, Tizazu. 2016. Synthesis and Assessment of Antibacterial Activities of Ruthenium(III) Mixed Ligand Complexes Containing 1,10-Phenanthroline and Guanide. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096789
Modern Language Association (MLA)
Abebe, Atakilt& Hailemariam, Tizazu. Synthesis and Assessment of Antibacterial Activities of Ruthenium(III) Mixed Ligand Complexes Containing 1,10-Phenanthroline and Guanide. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096789
American Medical Association (AMA)
Abebe, Atakilt& Hailemariam, Tizazu. Synthesis and Assessment of Antibacterial Activities of Ruthenium(III) Mixed Ligand Complexes Containing 1,10-Phenanthroline and Guanide. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096789