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A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro
المؤلفون المشاركون
Zhao, Yu
Hu, Yi-Yang
Wang, Wen-jing
Liu, Qian
Zheng, Qing-shan
Tian, Hua-jie
Yao, Dong-sheng
Liu, Lin
Feng, Qin
Tang, Ya-jun
Meng, Sheng-xi
Peng, Jing-hua
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study is to investigate the therapeutic effects of the recipe composed of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide (named ACG) on experimental nonalcoholic fatty liver (NAFL).
The research was divided into two parts as screening experiment and verification experiment.
In the screening experiment, we used high-fat diet (HFD) induced NAFL rat model and uniform design to get the recipe from five Chinese herbal active components.
In the verification experiment, HFD induced fatty liver rat and mouse NAFL models and free fatty acid (FFA) induced HepG2 cell model were used to verify the effects of ACG.
According to the multiple regression equation of the hepatic triglyceride (TG) contents of each group in the screening experiment, the recipe ACG was obtained and the doses of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide for rats were 266.67, 3.33, and 45 mg/kg, respectively.
The results of verification experiment verified that ACG could significantly reduce hepatic TG contents of NAFL rats and mice, as well as the cellular TG content of FFA-induced HepG2 cells.
ACG could also improve HOMA-IR and hepatic mitochondrial ultrastructure of NAFL mice.
Our study verified that ACG recipe could regulate lipid metabolism of NAFL in vivo and in vitro.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Sheng-xi& Liu, Qian& Tang, Ya-jun& Wang, Wen-jing& Zheng, Qing-shan& Tian, Hua-jie…[et al.]. 2016. A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Sheng-xi…[et al.]. A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1096808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Sheng-xi& Liu, Qian& Tang, Ya-jun& Wang, Wen-jing& Zheng, Qing-shan& Tian, Hua-jie…[et al.]. A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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