A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro
Joint Authors
Zhao, Yu
Hu, Yi-Yang
Wang, Wen-jing
Liu, Qian
Zheng, Qing-shan
Tian, Hua-jie
Yao, Dong-sheng
Liu, Lin
Feng, Qin
Tang, Ya-jun
Meng, Sheng-xi
Peng, Jing-hua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study is to investigate the therapeutic effects of the recipe composed of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide (named ACG) on experimental nonalcoholic fatty liver (NAFL).
The research was divided into two parts as screening experiment and verification experiment.
In the screening experiment, we used high-fat diet (HFD) induced NAFL rat model and uniform design to get the recipe from five Chinese herbal active components.
In the verification experiment, HFD induced fatty liver rat and mouse NAFL models and free fatty acid (FFA) induced HepG2 cell model were used to verify the effects of ACG.
According to the multiple regression equation of the hepatic triglyceride (TG) contents of each group in the screening experiment, the recipe ACG was obtained and the doses of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide for rats were 266.67, 3.33, and 45 mg/kg, respectively.
The results of verification experiment verified that ACG could significantly reduce hepatic TG contents of NAFL rats and mice, as well as the cellular TG content of FFA-induced HepG2 cells.
ACG could also improve HOMA-IR and hepatic mitochondrial ultrastructure of NAFL mice.
Our study verified that ACG recipe could regulate lipid metabolism of NAFL in vivo and in vitro.
American Psychological Association (APA)
Meng, Sheng-xi& Liu, Qian& Tang, Ya-jun& Wang, Wen-jing& Zheng, Qing-shan& Tian, Hua-jie…[et al.]. 2016. A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096808
Modern Language Association (MLA)
Meng, Sheng-xi…[et al.]. A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1096808
American Medical Association (AMA)
Meng, Sheng-xi& Liu, Qian& Tang, Ya-jun& Wang, Wen-jing& Zheng, Qing-shan& Tian, Hua-jie…[et al.]. A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096808