MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?
المؤلفون المشاركون
Rinke, Sven
Ziebolz, Dirk
Schmalz, Gerhard
Li, Simin
Burkhardt, Ralph
Krause, Felix
Haak, Rainer
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The aim of this review is to discuss current findings regarding the roles of miRNAs in periodontal diseases and the potential use of saliva as a diagnostic medium for corresponding miRNA investigations.
For periodontal disease, investigations have been restricted to tissue samples and five miRNAs, that is, miR-142-3p, miR-146a, miR-155, miR-203, and miR-223, were repeatedly validated in vivo and in vitro by different validation methods.
Particularly noticeable are the small sample sizes, different internal controls, and different case definitions of periodontitis in in vivo studies.
Beside of that, the validated miRNAs are associated with inflammation and therefore with various diseases.
Furthermore, several studies successfully explored the use of salivary miRNA species for the diagnosis of oral cancer.
Different cancer types were investigated and heterogeneous methodology was used; moreover, no overlap of results was found.
In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable.
In principle, a salivary miRNA diagnostic method seems feasible.
However, standardized criteria and protocols for preanalytics, measurements, and analysis should be established to obtain comparable results across different studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schmalz, Gerhard& Li, Simin& Burkhardt, Ralph& Rinke, Sven& Krause, Felix& Haak, Rainer…[et al.]. 2016. MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096809
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schmalz, Gerhard…[et al.]. MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1096809
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schmalz, Gerhard& Li, Simin& Burkhardt, Ralph& Rinke, Sven& Krause, Felix& Haak, Rainer…[et al.]. MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096809
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096809
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر