MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?
Joint Authors
Rinke, Sven
Ziebolz, Dirk
Schmalz, Gerhard
Li, Simin
Burkhardt, Ralph
Krause, Felix
Haak, Rainer
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The aim of this review is to discuss current findings regarding the roles of miRNAs in periodontal diseases and the potential use of saliva as a diagnostic medium for corresponding miRNA investigations.
For periodontal disease, investigations have been restricted to tissue samples and five miRNAs, that is, miR-142-3p, miR-146a, miR-155, miR-203, and miR-223, were repeatedly validated in vivo and in vitro by different validation methods.
Particularly noticeable are the small sample sizes, different internal controls, and different case definitions of periodontitis in in vivo studies.
Beside of that, the validated miRNAs are associated with inflammation and therefore with various diseases.
Furthermore, several studies successfully explored the use of salivary miRNA species for the diagnosis of oral cancer.
Different cancer types were investigated and heterogeneous methodology was used; moreover, no overlap of results was found.
In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable.
In principle, a salivary miRNA diagnostic method seems feasible.
However, standardized criteria and protocols for preanalytics, measurements, and analysis should be established to obtain comparable results across different studies.
American Psychological Association (APA)
Schmalz, Gerhard& Li, Simin& Burkhardt, Ralph& Rinke, Sven& Krause, Felix& Haak, Rainer…[et al.]. 2016. MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096809
Modern Language Association (MLA)
Schmalz, Gerhard…[et al.]. MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1096809
American Medical Association (AMA)
Schmalz, Gerhard& Li, Simin& Burkhardt, Ralph& Rinke, Sven& Krause, Felix& Haak, Rainer…[et al.]. MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach?. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096809