Differentially Expressed miRNAs in Tumor, Adjacent, and Normal Tissues of Lung Adenocarcinoma
المؤلفون المشاركون
Tian, Fei
Li, Rui
Chen, Zhenzhu
Shen, Yanting
Lu, Jiafeng
Xie, Xueying
Ge, Qinyu
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Lung cancer is the leading cause of cancer deaths.
Non-small-cell lung cancer (NSCLC) is the major type of lung cancer.
The aim of this study was to characterize the expression profiles of miRNAs in adenocarcinoma (AC), one major subtype of NSCLC.
In this study, the miRNAs were detected in normal, adjacent, and tumor tissues by next-generation sequencing.
Then the expression levels of differential miRNAs were quantified by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
In the results, 259, 401, and 389 miRNAs were detected in tumor, adjacent, and normal tissues of pooled AC samples, respectively.
In addition, for the first time we have found that miR-21-5p and miR-196a-5p were gradually upregulated from normal to adjacent to tumor tissues; miR-218-5p was gradually downregulated with 2-fold or greater change in AC tissues.
These 3 miRNAs were validated by qRT-PCR.
Lastly, we predicted target genes of these 3 miRNAs and enriched the potential functions and regulatory pathways.
The aberrant miR-21-5p, miR-196a-5p, and miR-218-5p may become biomarkers for diagnosis and prognosis of lung adenocarcinoma.
This research may be useful for lung adenocarcinoma diagnosis and the study of pathology in lung cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Fei& Li, Rui& Chen, Zhenzhu& Shen, Yanting& Lu, Jiafeng& Xie, Xueying…[et al.]. 2016. Differentially Expressed miRNAs in Tumor, Adjacent, and Normal Tissues of Lung Adenocarcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096878
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Fei…[et al.]. Differentially Expressed miRNAs in Tumor, Adjacent, and Normal Tissues of Lung Adenocarcinoma. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096878
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Fei& Li, Rui& Chen, Zhenzhu& Shen, Yanting& Lu, Jiafeng& Xie, Xueying…[et al.]. Differentially Expressed miRNAs in Tumor, Adjacent, and Normal Tissues of Lung Adenocarcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096878
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096878
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر