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Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?
المؤلفون المشاركون
Cai, Bin
Roodrajeetsing, Gopaul
Luo, Yu-long
Wang, Shi-jun
Wei, Wei-yuan
Zhang, Xue-hui
Huang, Wei
Li, Tong
Zhang, Meng
Wu, Nan
Zhang, Sen
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Citrulline (Cit) supplementation was proposed to serve as a therapeutic intervention to restore arginine (Arg) concentrations and improve related functions in sepsis.
This study explored whether citrulline had positive effects on liver injury and cytokine release in the early stages of sepsis.
The cecal ligation and puncture (CLP) model was utilized in our study.
Rats were divided into four groups: normal, Cit, CLP, and CLP+Cit.
The CLP group and CLP+Cit group were separated into 6-, 12-, and 24-hour groups, according to the time points of sacrifice after surgery.
Intragastric administration of L-citrulline was applied to rats in Cit and CLP+Cit groups before surgery.
Serum AST and ALT levels and levels of MDA, SOD, NO, and iNOS in the liver tissues were evaluated.
Plasma concentrations of Cit and Arg were assessed using HPLC-MS/MS.
Serum concentrations of cytokines and chemokines were calculated by Luminex.
Results showed SOD activities of CLP+Cit groups were significantly higher than that of CLP groups, contrasting with the MDA and NO levels which were significantly lower in CLP+Cit groups than in CLP groups.
In addition, plasma concentrations of TNF-α, IL-6, and IL-1β were significantly lower in the CLP+Cit 6-hour group than in the CLP 6-hour group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Bin& Luo, Yu-long& Wang, Shi-jun& Wei, Wei-yuan& Zhang, Xue-hui& Huang, Wei…[et al.]. 2016. Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096892
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Bin…[et al.]. Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096892
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Bin& Luo, Yu-long& Wang, Shi-jun& Wei, Wei-yuan& Zhang, Xue-hui& Huang, Wei…[et al.]. Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096892
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096892
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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