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Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?
Joint Authors
Cai, Bin
Roodrajeetsing, Gopaul
Luo, Yu-long
Wang, Shi-jun
Wei, Wei-yuan
Zhang, Xue-hui
Huang, Wei
Li, Tong
Zhang, Meng
Wu, Nan
Zhang, Sen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Citrulline (Cit) supplementation was proposed to serve as a therapeutic intervention to restore arginine (Arg) concentrations and improve related functions in sepsis.
This study explored whether citrulline had positive effects on liver injury and cytokine release in the early stages of sepsis.
The cecal ligation and puncture (CLP) model was utilized in our study.
Rats were divided into four groups: normal, Cit, CLP, and CLP+Cit.
The CLP group and CLP+Cit group were separated into 6-, 12-, and 24-hour groups, according to the time points of sacrifice after surgery.
Intragastric administration of L-citrulline was applied to rats in Cit and CLP+Cit groups before surgery.
Serum AST and ALT levels and levels of MDA, SOD, NO, and iNOS in the liver tissues were evaluated.
Plasma concentrations of Cit and Arg were assessed using HPLC-MS/MS.
Serum concentrations of cytokines and chemokines were calculated by Luminex.
Results showed SOD activities of CLP+Cit groups were significantly higher than that of CLP groups, contrasting with the MDA and NO levels which were significantly lower in CLP+Cit groups than in CLP groups.
In addition, plasma concentrations of TNF-α, IL-6, and IL-1β were significantly lower in the CLP+Cit 6-hour group than in the CLP 6-hour group.
American Psychological Association (APA)
Cai, Bin& Luo, Yu-long& Wang, Shi-jun& Wei, Wei-yuan& Zhang, Xue-hui& Huang, Wei…[et al.]. 2016. Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096892
Modern Language Association (MLA)
Cai, Bin…[et al.]. Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096892
American Medical Association (AMA)
Cai, Bin& Luo, Yu-long& Wang, Shi-jun& Wei, Wei-yuan& Zhang, Xue-hui& Huang, Wei…[et al.]. Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096892