Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis
المؤلفون المشاركون
Wang, Gui-Jun
Wang, Yue
Teng, Yong-Sheng
Sun, Fa-Lv
Xiang, Hong
Liu, Jian-Jun
Xia, Shi-Lin
Zhang, Gui-Xin
Chen, Hai-Long
Shang, Dong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Severe acute pancreatitis (SAP) results in high mortality.
This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS).
Many studies have reported the beneficial effects of emodin against SAP with SIRS.
However, the exact mechanism underlying the effect of emodin remains unclear.
This study was designed to explore the protective effects and underlying mechanisms of emodin against SIRS in rats with SAP.
In the present study, cytosolic Ca2+ levels, calpain 1 activity, and the expression levels of the active fragments of caspases 12 and 3 decreased in neutrophils from rats with SAP and increased after treatment with emodin.
Delayed neutrophil apoptosis occurred in rats with SAP and emodin was able to reverse this delayed apoptosis and inhibit SIRS.
The effect of emodin on calpain 1 activity, the expression levels of the active fragments of caspases 12 and 3, neutrophil apoptosis, and SIRS scores were attenuated by PD150606 (an inhibitor of calpain).
These results suggest that emodin inhibits SIRS in rats with SAP by inducing circulating neutrophil apoptosis via the Ca2+-calpain 1-caspase 12-caspase 3 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Gui-Jun& Wang, Yue& Teng, Yong-Sheng& Sun, Fa-Lv& Xiang, Hong& Liu, Jian-Jun…[et al.]. 2016. Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096952
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Gui-Jun…[et al.]. Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096952
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Gui-Jun& Wang, Yue& Teng, Yong-Sheng& Sun, Fa-Lv& Xiang, Hong& Liu, Jian-Jun…[et al.]. Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096952
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096952
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر