Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis
Joint Authors
Wang, Gui-Jun
Wang, Yue
Teng, Yong-Sheng
Sun, Fa-Lv
Xiang, Hong
Liu, Jian-Jun
Xia, Shi-Lin
Zhang, Gui-Xin
Chen, Hai-Long
Shang, Dong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Severe acute pancreatitis (SAP) results in high mortality.
This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS).
Many studies have reported the beneficial effects of emodin against SAP with SIRS.
However, the exact mechanism underlying the effect of emodin remains unclear.
This study was designed to explore the protective effects and underlying mechanisms of emodin against SIRS in rats with SAP.
In the present study, cytosolic Ca2+ levels, calpain 1 activity, and the expression levels of the active fragments of caspases 12 and 3 decreased in neutrophils from rats with SAP and increased after treatment with emodin.
Delayed neutrophil apoptosis occurred in rats with SAP and emodin was able to reverse this delayed apoptosis and inhibit SIRS.
The effect of emodin on calpain 1 activity, the expression levels of the active fragments of caspases 12 and 3, neutrophil apoptosis, and SIRS scores were attenuated by PD150606 (an inhibitor of calpain).
These results suggest that emodin inhibits SIRS in rats with SAP by inducing circulating neutrophil apoptosis via the Ca2+-calpain 1-caspase 12-caspase 3 signaling pathway.
American Psychological Association (APA)
Wang, Gui-Jun& Wang, Yue& Teng, Yong-Sheng& Sun, Fa-Lv& Xiang, Hong& Liu, Jian-Jun…[et al.]. 2016. Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096952
Modern Language Association (MLA)
Wang, Gui-Jun…[et al.]. Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096952
American Medical Association (AMA)
Wang, Gui-Jun& Wang, Yue& Teng, Yong-Sheng& Sun, Fa-Lv& Xiang, Hong& Liu, Jian-Jun…[et al.]. Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096952