Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice
المؤلفون المشاركون
Bhattarakosol, Parvapan
Patumraj, Suthiluk
Changtam, Chatchawan
Yoysungnoen-Chintana, Pornphrom
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Tetrahydrocurcumin (THC) is a stable metabolite of curcumin (CUR) in physiological systems.
The mechanism underlying the anticancer effect of THC is not completely understood.
In the present study, we investigated the effects of THC on tumor growth and cellular signaling in cervical cancer xenografts in nude mice.
Cervical cancer cells (CaSki) were subcutaneously injected in nude mice to establish tumors.
One month after the injection, mice were orally administered vehicle or 100, 300, and 500 mg/kg of THC daily for 30 consecutive days.
Relative tumor volume (RTV) was measured every 3-4 days.
COX-2, EGFR, p-ERK1&2, p-AKT, and Ki-67 expressions were measured by immunohistochemistry whereas cell apoptosis was detected by TUNELS method.
THC treatments at the doses of 100, 300, and 500 mg/kg statistically retarded the RTV by 70.40%, 76.41%, and 77.93%, respectively.
The CaSki + vehicle group also showed significantly increased COX-2, EGFR, p-ERK1&2, and p-AKT; however they were attenuated by all treatments with THC.
Ki-67 overexpression and a decreasing of cell apoptosis were found in CaSki + vehicle group, but these findings were reversed after the THC treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yoysungnoen-Chintana, Pornphrom& Bhattarakosol, Parvapan& Changtam, Chatchawan& Patumraj, Suthiluk. 2016. Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096963
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yoysungnoen-Chintana, Pornphrom…[et al.]. Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096963
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yoysungnoen-Chintana, Pornphrom& Bhattarakosol, Parvapan& Changtam, Chatchawan& Patumraj, Suthiluk. Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096963
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096963
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر