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Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice
Joint Authors
Bhattarakosol, Parvapan
Patumraj, Suthiluk
Changtam, Chatchawan
Yoysungnoen-Chintana, Pornphrom
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tetrahydrocurcumin (THC) is a stable metabolite of curcumin (CUR) in physiological systems.
The mechanism underlying the anticancer effect of THC is not completely understood.
In the present study, we investigated the effects of THC on tumor growth and cellular signaling in cervical cancer xenografts in nude mice.
Cervical cancer cells (CaSki) were subcutaneously injected in nude mice to establish tumors.
One month after the injection, mice were orally administered vehicle or 100, 300, and 500 mg/kg of THC daily for 30 consecutive days.
Relative tumor volume (RTV) was measured every 3-4 days.
COX-2, EGFR, p-ERK1&2, p-AKT, and Ki-67 expressions were measured by immunohistochemistry whereas cell apoptosis was detected by TUNELS method.
THC treatments at the doses of 100, 300, and 500 mg/kg statistically retarded the RTV by 70.40%, 76.41%, and 77.93%, respectively.
The CaSki + vehicle group also showed significantly increased COX-2, EGFR, p-ERK1&2, and p-AKT; however they were attenuated by all treatments with THC.
Ki-67 overexpression and a decreasing of cell apoptosis were found in CaSki + vehicle group, but these findings were reversed after the THC treatments.
American Psychological Association (APA)
Yoysungnoen-Chintana, Pornphrom& Bhattarakosol, Parvapan& Changtam, Chatchawan& Patumraj, Suthiluk. 2016. Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096963
Modern Language Association (MLA)
Yoysungnoen-Chintana, Pornphrom…[et al.]. Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096963
American Medical Association (AMA)
Yoysungnoen-Chintana, Pornphrom& Bhattarakosol, Parvapan& Changtam, Chatchawan& Patumraj, Suthiluk. Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096963