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Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor
المؤلفون المشاركون
Mahmud, Zabed
Malik, Syeda Umme Fahmida
Ahmed, Jahed
Azad, Abul Kalam
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Single-nucleotide polymorphisms (SNPs) associated with complex disorders can create, destroy, or modify protein coding sites.
Single amino acid substitutions in the insulin receptor (INSR) are the most common forms of genetic variations that account for various diseases like Donohue syndrome or Leprechaunism, Rabson-Mendenhall syndrome, and type A insulin resistance.
We analyzed the deleterious nonsynonymous SNPs (nsSNPs) in INSR gene based on different computational methods.
Analysis of INSR was initiated with PROVEAN followed by PolyPhen and I-Mutant servers to investigate the effects of 57 nsSNPs retrieved from database of SNP (dbSNP).
A total of 18 mutations that were found to exert damaging effects on the INSR protein structure and function were chosen for further analysis.
Among these mutations, our computational analysis suggested that 13 nsSNPs decreased protein stability and might have resulted in loss of function.
Therefore, the probability of their involvement in disease predisposition increases.
In the lack of adequate prior reports on the possible deleterious effects of nsSNPs, we have systematically analyzed and characterized the functional variants in coding region that can alter the expression and function of INSR gene.
In silico characterization of nsSNPs affecting INSR gene function can aid in better understanding of genetic differences in disease susceptibility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmud, Zabed& Malik, Syeda Umme Fahmida& Ahmed, Jahed& Azad, Abul Kalam. 2016. Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097014
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmud, Zabed…[et al.]. Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097014
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmud, Zabed& Malik, Syeda Umme Fahmida& Ahmed, Jahed& Azad, Abul Kalam. Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097014
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097014
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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