![](/images/graphics-bg.png)
Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor
Joint Authors
Mahmud, Zabed
Malik, Syeda Umme Fahmida
Ahmed, Jahed
Azad, Abul Kalam
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Single-nucleotide polymorphisms (SNPs) associated with complex disorders can create, destroy, or modify protein coding sites.
Single amino acid substitutions in the insulin receptor (INSR) are the most common forms of genetic variations that account for various diseases like Donohue syndrome or Leprechaunism, Rabson-Mendenhall syndrome, and type A insulin resistance.
We analyzed the deleterious nonsynonymous SNPs (nsSNPs) in INSR gene based on different computational methods.
Analysis of INSR was initiated with PROVEAN followed by PolyPhen and I-Mutant servers to investigate the effects of 57 nsSNPs retrieved from database of SNP (dbSNP).
A total of 18 mutations that were found to exert damaging effects on the INSR protein structure and function were chosen for further analysis.
Among these mutations, our computational analysis suggested that 13 nsSNPs decreased protein stability and might have resulted in loss of function.
Therefore, the probability of their involvement in disease predisposition increases.
In the lack of adequate prior reports on the possible deleterious effects of nsSNPs, we have systematically analyzed and characterized the functional variants in coding region that can alter the expression and function of INSR gene.
In silico characterization of nsSNPs affecting INSR gene function can aid in better understanding of genetic differences in disease susceptibility.
American Psychological Association (APA)
Mahmud, Zabed& Malik, Syeda Umme Fahmida& Ahmed, Jahed& Azad, Abul Kalam. 2016. Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097014
Modern Language Association (MLA)
Mahmud, Zabed…[et al.]. Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097014
American Medical Association (AMA)
Mahmud, Zabed& Malik, Syeda Umme Fahmida& Ahmed, Jahed& Azad, Abul Kalam. Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097014