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Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
المؤلفون المشاركون
Lizcano, Fernando
Vargas, Diana
Rosales, Wendy
Carulla, Juan
García, Jeison
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells.
However, the role of the jumonji family of demethylases in the development of cardiac hypertrophy remains elusive.
In this study, the presence of different histone demethylases in cardiac cells was evaluated after hypertrophy was induced with neurohormones.
A cell line from rat cardiomyocytes was used as a biological model.
The phenotypic profiles of the cells, as well as the expression of histone demethylases, were studied through immunofluorescence, transient transfection, western blot, and qRT-PCR analysis after inducing hypertrophy by angiotensin II and endothelin-1.
An increase in fetal gene expression (ANP, BNP, and β-MHC) was observed in cardiomyocytes after treatment with angiotensin II and endothelin-1.
A significant increase in JMJD2A expression, but not in UTX or JMJD2C expression, was observed.
When JMJD2A was overexpressed in cardiomyocytes through transient transfection, the effect of neurohormones on fetal cardiac gene expression was increased.
We conclude that JMJD2A plays a principal role in the regulation of fetal cardiac genes, which increase in expression during the pathological hypertrophic process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rosales, Wendy& Carulla, Juan& García, Jeison& Vargas, Diana& Lizcano, Fernando. 2016. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097124
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rosales, Wendy…[et al.]. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097124
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rosales, Wendy& Carulla, Juan& García, Jeison& Vargas, Diana& Lizcano, Fernando. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097124
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097124
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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