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Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
Joint Authors
Lizcano, Fernando
Vargas, Diana
Rosales, Wendy
Carulla, Juan
García, Jeison
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells.
However, the role of the jumonji family of demethylases in the development of cardiac hypertrophy remains elusive.
In this study, the presence of different histone demethylases in cardiac cells was evaluated after hypertrophy was induced with neurohormones.
A cell line from rat cardiomyocytes was used as a biological model.
The phenotypic profiles of the cells, as well as the expression of histone demethylases, were studied through immunofluorescence, transient transfection, western blot, and qRT-PCR analysis after inducing hypertrophy by angiotensin II and endothelin-1.
An increase in fetal gene expression (ANP, BNP, and β-MHC) was observed in cardiomyocytes after treatment with angiotensin II and endothelin-1.
A significant increase in JMJD2A expression, but not in UTX or JMJD2C expression, was observed.
When JMJD2A was overexpressed in cardiomyocytes through transient transfection, the effect of neurohormones on fetal cardiac gene expression was increased.
We conclude that JMJD2A plays a principal role in the regulation of fetal cardiac genes, which increase in expression during the pathological hypertrophic process.
American Psychological Association (APA)
Rosales, Wendy& Carulla, Juan& García, Jeison& Vargas, Diana& Lizcano, Fernando. 2016. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097124
Modern Language Association (MLA)
Rosales, Wendy…[et al.]. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097124
American Medical Association (AMA)
Rosales, Wendy& Carulla, Juan& García, Jeison& Vargas, Diana& Lizcano, Fernando. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097124