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Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease
المؤلفون المشاركون
Wang, Junnan
Yan, Youyou
Song, Dandan
Liu, Bin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Coronary collateral circulation (CCC), an alternative blood supply for ischemic myocardium, improves survival rates among patients with coronary artery disease (CAD).
However, there remains a lack of biomarkers to discriminate between patients with poor or good CCC.
In this study, we aimed to observe the relationship between plasma microRNA-146a (miR-146a) levels and the coronary collateral circulation (CCC).
Additionally, we aimed to explore whether the plasma miR-146a level could serve as a blood-based biomarker for CCC in patients with CAD.
We measured the plasma levels of vascular endothelial growth factor A (VEGF-A) and miR-146a in patients with CCC by ELISA and real-time PCR, respectively, according to the Rentrop grades.
The results showed that the plasma miR-146a level is significantly increased in CAD patients with good CCC and significantly decreased in those with poor CCC.
In contrast, although VEGFA expression in patients followed a similar trend as the CCC, the differences between the groups were not statistically significant.
There was a positive correlation between plasma miR-146a levels and the Rentrop grading.
In addition, receiver operator characteristic analysis showed that miR-146a could be a potent biomarker for identifying patients with poor CCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Junnan& Yan, Youyou& Song, Dandan& Liu, Bin. 2016. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097725
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Junnan…[et al.]. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097725
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Junnan& Yan, Youyou& Song, Dandan& Liu, Bin. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097725
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097725
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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