Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease
Joint Authors
Wang, Junnan
Yan, Youyou
Song, Dandan
Liu, Bin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Coronary collateral circulation (CCC), an alternative blood supply for ischemic myocardium, improves survival rates among patients with coronary artery disease (CAD).
However, there remains a lack of biomarkers to discriminate between patients with poor or good CCC.
In this study, we aimed to observe the relationship between plasma microRNA-146a (miR-146a) levels and the coronary collateral circulation (CCC).
Additionally, we aimed to explore whether the plasma miR-146a level could serve as a blood-based biomarker for CCC in patients with CAD.
We measured the plasma levels of vascular endothelial growth factor A (VEGF-A) and miR-146a in patients with CCC by ELISA and real-time PCR, respectively, according to the Rentrop grades.
The results showed that the plasma miR-146a level is significantly increased in CAD patients with good CCC and significantly decreased in those with poor CCC.
In contrast, although VEGFA expression in patients followed a similar trend as the CCC, the differences between the groups were not statistically significant.
There was a positive correlation between plasma miR-146a levels and the Rentrop grading.
In addition, receiver operator characteristic analysis showed that miR-146a could be a potent biomarker for identifying patients with poor CCC.
American Psychological Association (APA)
Wang, Junnan& Yan, Youyou& Song, Dandan& Liu, Bin. 2016. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097725
Modern Language Association (MLA)
Wang, Junnan…[et al.]. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097725
American Medical Association (AMA)
Wang, Junnan& Yan, Youyou& Song, Dandan& Liu, Bin. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097725