Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity
المؤلفون المشاركون
Echeverría, Patricia
Estany, Carla
Clotet, Bonaventura
Negredo, Eugenia
Bonjoch, Anna
Puig, Jordi
Pérez-Alvarez, Nuria
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Prospective studies about the reversibility of tenofovir disoproxil fumarate- (TDF-) related renal impairment remain scarce.
Methods.
This is an observational prospective study including all patients that presented at our HIV Unit who interrupted TDF owing to nephrotoxicity.
We assessed the evolution of renal parameters after discontinuation of this drug.
Results.
We included 59 patients, who were followed up for 72 weeks.
Most were male (41, 69.5%), median (IQR) age was 53 (44; 58) years, and median time receiving TDF-containing regimens was 55.4 (28; 87.7) months.
Most patients were receiving PI-based treatments (67%).
At the final visit, most of the subjects showed complete recovery (35, 59.3%) or improvement (13 subjects, 22%).
Significant improvements were observed in creatinine levels (from 84.9 [73.8; 97.5] to 78 [69.6; 91] μmol/L, p=0.013), estimated glomerular filtration rate (eGFR, CKD EPI equation, from 87.7 [67; 99] to 89.9 [73.6; 99.3] mL/min/1.73 m2, p=0.017), and number of patients with eGFR <60 mL/min/1.73 m2 (from 9 [15.3%] to 1 [1.7%], p=0.031).
A trend toward significance was observed in abnormal urine proteinuria/creatinine ratio (from 22 [37%] to 8 [13.6%], p=0.057).
Conclusions.
Our results corroborate the high frequency of complete or partial renal recovery in patients receiving TDF-containing regimens who discontinued therapy owing to nephrotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bonjoch, Anna& Echeverría, Patricia& Pérez-Alvarez, Nuria& Puig, Jordi& Estany, Carla& Clotet, Bonaventura…[et al.]. 2016. Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bonjoch, Anna…[et al.]. Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bonjoch, Anna& Echeverría, Patricia& Pérez-Alvarez, Nuria& Puig, Jordi& Estany, Carla& Clotet, Bonaventura…[et al.]. Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر